Detección de benzodiacepinas en sujetos fallecidos por Reacción Aguda a Drogas en Galicia (1997-2011)

Abstract

Death due to acute drug reactions is the most serious problem of substance abuse and one of the leading causes of mortality among addict population. Toxicological analyses carried out on deceased shows the presence of multiple substances due to a pattern poly-drug use expansion. The most common and dangerous combination is that mix several central nervous system depressants, opiates with benzodiazepines and/or alcohol in particular. This fact, together with the extension of the use and abuse of these psychoactive drugs, with or without medical prescription, determine that these substances are often detected in deceased by this cause. We studied all deceased by acute drug reactions (n=805) in Galicia in the period among 1997- 2011. Most of them are males (91.2%), singles (47.7%), with an average age of 34.3 years and with long history of consumption. The presence of benzodiazepines was detected in 42.4% of deceased. Significant differences in this percentage throughout of this study are observed without a clear trend. Most commonly found substance is alprazolam followed by nordiazepam, diazepam and lormetazepam.