The obestatin/GPR39 systemfrom satellite cell regulation to its applicability in Duchenne muscular dystrophy

  1. González Sánchez, Jessica
Dirixida por:
  1. Jesús Pérez Camiña Director
  2. Felipe Casanueva Freijó Director
  3. José Luis Relova Quinteiro Director

Universidade de defensa: Universidade de Santiago de Compostela

Fecha de defensa: 04 de abril de 2019

Tribunal:
  1. Amelia Aranega Jiménez Presidente/a
  2. Rosalía Gallego Gómez Secretaria
  3. Eusebio Perdiguero Santamaría Vogal

Tipo: Tese

Teseo: 587053 DIALNET

Resumo

The obestatin/GPR39 system functions as a mediator of skeletal muscle determination, maintenance, and plasticity in physiological and pathological conditions. In satellite cells, the obestatin/GPR39 system acts as an autocrine factor regulating cell cycle progression and fate determination. In Duchenne muscular dystrophy, obestatin signalling addresses multiple pathways needed for phenotypic amelioration, including regulation of myofibre regeneration, activation of the slow oxidative myofibre program, regulation of proteasomal signalling, stabilization of the sarcolemma and induction of corrective autophagy. The results point to the obestatin/GPR39 system as a practical and effective target for future Duchenne muscular dystrophy therapies.