Administration of intra-articular hydrogen sulphide reduces the severity of osteoarthritis in vivo

  1. E.F. Burguera 1
  2. A. Vela-Anero 2
  3. T. Hermida-Gomez 1
  4. P. Filgueira Fernandez 1
  5. L. Gato-Calvo 1
  6. C. Vaamonde-García 2
  7. F.J. Blanco 1
  8. R. Meijide Failde 2
  1. 1 issue Engineering Unit, Rheumatology Research Group, INIBIC-Hospital Universitario A Coruña, A Coruña, Spain
  2. 2 Cell Therapy and Regenerative Medicine Group, Department of Medicine, University of A Coruña, A Coruña, Spain
Revista:
Boletín de la Sociedad Española de Hidrología Médica

ISSN: 0214-2813

Ano de publicación: 2018

Número: 1

Páxinas: 90-91

Tipo: Artigo

DOI: 10.23853/BSEHM.2018.0602 DIALNET GOOGLE SCHOLAR lock_openAcceso aberto editor

Outras publicacións en: Boletín de la Sociedad Española de Hidrología Médica

Obxectivos de Desenvolvemento Sustentable

Resumo

Purpose: Osteoarthritis (OA) results in progressive cartilage destruction leading to joint malfunction. Current treatments, mostly symptomatic, are not able to stop or retard the progression of the disease. Hydrogen sulphide is a small gaseous molecule that has shown to prevent cartilage degradation as well as to exert antiinflammatory effects in in vitro models of OA, and is the active component of sulphurous minero-medicinal waters. The purpose here was to evaluate the effects of administering an H2S-producing compound, intra-articularly, in an experimental model of OA.

Fonte de datos: Dialnet