Efectos celulares y moleculares de nanopartículas de magnetita en células neuronales humanas

  1. Natalia Fernández-Bertólez 1
  2. Gözde Kiliç 1
  3. Carla Costa 2
  4. Fátima Brandao 2
  5. Eduardo Pásaro 3
  6. João Paulo Teixeira 2
  7. Blanca Laffon 3
  8. Vanessa Valdiglesias 3
  1. 1 Grupo DICOMOSA, Departamento de Psicología, Área de Psicobiología, Universidade da Coruña; Departmento de Biología Celular y Molecular, Universidade da Coruña
  2. 2 Departmento de Saúde Ambiental, Instituto Nacional de Saúde Dr. Ricardo Jorge, Portugal; ISPUP-EPIUnit, Universidade do Porto
  3. 3 Grupo DICOMOSA, Departamento de Psicología, Área de Psicobiología, Universidade da Coruña
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Journal:
Revista Real Academia Galega de Ciencias

ISSN: 1135-5417

Year of publication: 2016

Issue: 35

Pages: 65-103

Type: Article

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More publications in: Revista Real Academia Galega de Ciencias

Abstract

Iron oxide nanoparticles (ION) have a great potential in many biomedical applications, but studies on their toxicity are still scarce. In this work, cytotoxic and genotoxic effect of silica-coated ION were characterized on human neuronal cells. In spite of being efficiently taken up by the cells, ION showed in general low cytotoxicity; positive results were only obtained at the highest concentrations and longest treatment times tested. Genotoxicity evaluations in serum-free medium were negative in all cases; in complete medium increase in primary DNA damage was observed, not related to double strand breaks or chromosome loss. The results obtained provide a better understanding of ION interaction with cell systems and its possible consequences, especially on the nervous system.

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