Stents farmacoactivos frente a metálicos en pacientes tratados con angioplastia primaria.Análisis de un registro de 8 años

  1. Alfredo Redondo Diéguez 1
  2. B. Cid Álvarez 1
  3. R. Trillo Nouche 1
  4. Alejandro Ávila Carrillo 1
  5. Belén Álvarez Álvarez 1
  6. Fernando Gómez Peña 1
  7. Sanmartín Pena, Juan Carlos
  8. Diego López Otero 1
  9. José Ramón González Juanatey 1
  1. 1 Servicio de Cardiología, Complexo Hospitalario Universitario de Santiago de Compostela (CHUS), Centro de Investigación Biomédica en Red de Enfermedades Cardiovasculares (CIBERCV), Santiago de Compostela, A Coruña, España
Revista:
REC: Interventional Cardiology

ISSN: 2604-7276,  2604-7306

Ano de publicación: 2019

Volume: 1

Número: 1

Páxinas: 26-33

Tipo: Artigo

DOI: 10.24875/RECIC.M19000019 DIALNET GOOGLE SCHOLAR lock_openDialnet editor

Outras publicacións en: REC: Interventional Cardiology

Resumo

Introduction and objectives: Evidence of the long-term prognostic benefit of new generation drug-eluting stents (DES) is limited, especially in the context of primary percutaneous coronary interventions. The goal of this study was to compare the long-term prognostic impact of the implantation of DESs versus bare-metal stents (BMSs) in real-world patients undergoing primary percutaneous coronary interventions. Methods: A cohort study was conducted with 1499 consecutive patients diagnosed with ST-segment elevation myocardial infarction who underwent percutaneous coronary interventions between January 2008 and December 2015. A total of 24.9% of the patients received a DES. A matched propensity score analysis yielded 2 groups of 262 matched patients depending on whether they were treated with a DES or a BMS. Results: During follow-up (median 1015 days), the patients who received DES had a lower all-cause mortality rate (6.5% vs 12.2%; P = .049) a lower composite endpoint of major adverse cardiac events (16.4% vs 25.2%; P = .049) and a lower patient-oriented composite endpoint of death from any cause, myocardial infarction and revascularization at follow-up (12.6% vs 22.5%; P = .017). No differences were seen in the definite stent thrombosis rate. Conclusions: In our registry, in a real-world population of consecutive patients undergoing primary percutaneous coronary interventions, the use of DES versus BMS associated more survival and less clinically significant major adverse cardiac events and patient-oriented composite endpoints in a long-term follow-up, without any differences in stent thrombosis.

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Fonte de datos: Dialnet