Advances in Drug Delivery Strategies for Microbial Healthcare Products

  1. Ageitos, Jose Manuel 1
  2. Garcia-Fuentes, Marcos 1
  1. 1 Centre for Research in Molecular Medicine and Chronic Diseases (CiMUS) and Department of Pharmacology, Pharmacy and Pharmaceutical Technology, University of Santiago de Compostela, Santiago de Compostela, Spain
Libro:
Environmental Chemistry for a Sustainable World

ISSN: 2213-7114 2213-7122

ISBN: 9783030018801 9783030018818

Ano de publicación: 2019

Páxinas: 1-38

Tipo: Capítulo de libro

DOI: 10.1007/978-3-030-01881-8_1 GOOGLE SCHOLAR lock_openAcceso aberto editor

Obxectivos de Desenvolvemento Sustentable

Resumo

In wound healing, gene therapy strategies have the largest potential as new treatments for refractory chronic wounds. This potential of gene therapy stems from its capacity to regulate genes that reverse the key hallmarks driving chronic wound formation: inflammation, reduced angiogenesis, and impaired re-epithelization. Indeed, the most important strategies followed with gene therapy have been signalling supplementation and the inhibition of critical pathways that are dysregulated in chronic wounds. Gene therapies in wound healing can be delivered either by a systemic administration route or, more commonly, by local administration. The chapter briefly discusses a specific delivery platform of particular interest in tissue regeneration and wound healing referred to as a gene-activated matrix. The results from the clinical trials analysed to date have confirmed the safety of gene therapy strategies in chronic wound management but present an uncertain landscape regarding efficacy.

Referencias bibliográficas

  • Abdelghany SM, Quinn DJ, Ingram RJ et al (2012) Gentamicin-loaded nanoparticles show improved antimicrobial effects towards Pseudomonas aeruginosa infection. Int J Nanomed 7:4053–4063. https://doi.org/10.2147/IJN.S34341
  • Ageitos JM, Chuah J-A, Numata K (2016) Chapter 1. Design considerations for properties of nanocarriers on disposition and efficiency of drug and gene delivery. In: Braddock M (ed) Nanomedicines: design, delivery and detection. Royal Society of Chemistry, pp 1–22. https://doi.org/10.1039/9781782622536-00001
  • Ageitos JM, Sánchez-Pérez A, Calo-Mata P, Villa TG (2017) Antimicrobial peptides (AMPs): ancient compounds that represent novel weapons in the fight against bacteria. Biochem Pharmacol 133:117–138. https://doi.org/10.1016/j.bcp.2016.09.018
  • Ahire JJ, Dicks LMT (2014) Nisin incorporated with 2,3-dihydroxybenzoic acid in nanofibers inhibits biofilm formation by a methicillin-resistant strain of Staphylococcus aureus. Probiotics Antimicrob Proteins 7:52–59. https://doi.org/10.1007/s12602-014-9171-5
  • Aksungur P, Demirbilek M, Denkbaş EB et al (2011) Development and characterization of Cyclosporine A loaded nanoparticles for ocular drug delivery: cellular toxicity, uptake, and kinetic studies. J Control Release 151:286–294. https://doi.org/10.1016/j.jconrel.2011.01.010
  • Albright V, Zhuk I, Wang Y et al (2017) Self-defensive antibiotic-loaded layer-by-layer coatings: imaging of localized bacterial acidification and pH-triggering of antibiotic release. Acta Biomater. https://doi.org/10.1016/j.actbio.2017.08.012
  • Alipour M, Suntres ZE (2014) Liposomal antibiotic formulations for targeting the lungs in the treatment of Pseudomonas aeruginosa. Ther Deliv 5:409–427. https://doi.org/10.4155/tde.14.13
  • Ambrogi V, Perioli L, Ricci M et al (2008) Eudragit® and hydrotalcite-like anionic clay composite system for diclofenac colonic delivery. Microporous Mesoporous Mater 115:405–415. https://doi.org/10.1016/j.micromeso.2008.02.014
  • Anselmo AC, Mitragotri S (2016) Nanoparticles in the clinic. Bioeng Transl Med 1:10–29. https://doi.org/10.1002/btm2.10003
  • Anselmo AC, Prabhakarpandian B, Pant K, Mitragotri S (2017) Clinical and commercial translation of advanced polymeric nanoparticle systems: opportunities and material challenges. Transl Mater Res 4:14001. https://doi.org/10.1088/2053-1613/aa5468
  • Argenziano M, Banche G, Luganini A et al (2017) Vancomycin-loaded nanobubbles: a new platform for controlled antibiotic delivery against methicillin-resistant Staphylococcus aureus infections. Int J Pharm 523:176–188. https://doi.org/10.1016/j.ijpharm.2017.03.033
  • Arslan-Tontul S, Erbas M (2017) Single and double layered microencapsulation of probiotics by spray drying and spray chilling. LWT – Food Sci Technol 81:160–169. https://doi.org/10.1016/j.lwt.2017.03.060
  • Aviv M, Berdicevsky I, Zilberman M (2007) Gentamicin-loaded bioresorbable films for prevention of bacterial infections associated with orthopedic implants. J Biomed Mater Res Part A 83A:10–19. https://doi.org/10.1002/jbm.a.31184
  • Bachar G, Cohen K, Hod R et al (2011) Hyaluronan-grafted particle clusters loaded with Mitomycin C as selective nanovectors for primary head and neck cancers. Biomaterials 32:4840–4848. https://doi.org/10.1016/j.biomaterials.2011.03.040
  • Başaran E, Yenilmez E, Berkman MS et al (2014) Chitosan nanoparticles for ocular delivery of cyclosporine A. J Microencapsul 31:49–57. https://doi.org/10.3109/02652048.2013.805839
  • Battaglia L, D’Addino I, Peira E et al (2012) Solid lipid nanoparticles prepared by coacervation method as vehicles for ocular cyclosporine. J Drug Deliv Sci Technol 22:125–130. https://doi.org/10.1016/S1773-2247(12)50016-X
  • Betha S, Pamula Reddy B, Mohan Varma M et al (2015) Development of simvastatin electrospun fibers: a novel approach for sustained drug delivery. J Pharm Investig 45:13–22. https://doi.org/10.1007/s40005-014-0140-5
  • Bobo D, Robinson KJ, Islam J et al (2016) Nanoparticle-based medicines: a review of FDA-approved materials and clinical trials to date. Pharm Res 33:2373–2387. https://doi.org/10.1007/s11095-016-1958-5
  • Borhade V, Nair H, Hegde D (2008) Design and evaluation of self-microemulsifying drug delivery system (SMEDDS) of Tacrolimus. AAPS PharmSciTech 9:13–21. https://doi.org/10.1208/s12249-007-9014-8
  • Brandenburg KS, Rubinstein I, Sadikot RT, Önyüksel H (2012) Polymyxin B self-associated with phospholipid nanomicelles. Pharm Dev Technol 17:654–660. https://doi.org/10.3109/10837450.2011.572893
  • Bravo González RC, Huwyler J, Walter I et al (2002) Improved oral bioavailability of cyclosporin A in male Wistar rats: comparison of a Solutol HS 15 containing self-dispersing formulation and a microsuspension. Int J Pharm 245:143–151. https://doi.org/10.1016/S0378-5173(02)00339-3
  • Calo-Mata P, Ageitos JM, Böhme K, Barros-Velázquez J (2016) Intestinal microbiota: first barrier against gut-affecting pathogens. In: Villa TG, Vinas M (eds) New weapons to control bacterial growth. Springer International Publishing, Cham, pp 281–314. https://doi.org/10.1007/978-3-319-28368-5_12
  • Carmona-Ribeiro AM, Carrasco LD d M (2014) Novel formulations for antimicrobial peptides. Int J Mol Sci 15:18040–18083. https://doi.org/10.3390/ijms151018040
  • Chacón M, Molpeceres J, Berges L et al (1999) Stability and freeze-drying of cyclosporine loaded poly(D,L-lactide-glycolide) carriers. Eur J Pharm Sci 8:99–107. https://doi.org/10.1016/S0928-0987(98)00066-9
  • Chai F, Sun L, He X et al (2017) Doxorubicin-loaded poly (Lactic-co-glycolic acid) nanoparticles coated with chitosan/alginate by layer by layer technology for antitumor applications. Int J Nanomed 12:1791–1802. https://doi.org/10.2147/IJN.S130404
  • Chakraborty SP, Sahu SK, Mahapatra SK et al (2010) Nanoconjugated vancomycin: new opportunities for the development of anti-VRSA agents. Nanotechnology 21:105103. https://doi.org/10.1088/0957-4484/21/10/105103
  • Chang CC, Chen WC, Ho TF et al (2011) Development of natural anti-tumor drugs by microorganisms. J Biosci Bioeng 111:501–511. https://doi.org/10.1016/j.jbiosc.2010.12.026
  • Cheung RY, Ying Y, Rauth AM et al (2005) Biodegradable dextran-based microspheres for delivery of anticancer drug mitomycin C. Biomaterials 26:5375–5385. https://doi.org/10.1016/j.biomaterials.2005.01.050
  • Chiani M, Norouzian D, Shokrgozar MA et al (2017) Folic acid conjugated nanoliposomes as promising carriers for targeted delivery of bleomycin. Artif Cells Nanomed, Biotechnol 0:1–7. https://doi.org/10.1080/21691401.2017.1337029
  • Chifiriuc MC, Holban AM, Curutiu C et al (2016) Antibiotic drug delivery systems for the intracellular targeting of bacterial pathogens. In: Sezer AD (ed) Smart drug delivery system. InTech, pp 305–344. https://doi.org/10.5772/61327
  • Cohen-Sela E, Teitlboim S, Chorny M et al (2009) Single and double emulsion manufacturing techniques of an amphiphilic drug in PLGA nanoparticles: formulations of mithramycin and bioactivity. J Pharm Sci 98:1452–1462. https://doi.org/10.1002/jps.21527
  • Danhier F, Lecouturier N, Vroman B et al (2009) Paclitaxel-loaded PEGylated PLGA-based nanoparticles: in vitro and in vivo evaluation. J Control Release 133:11–17. https://doi.org/10.1016/j.jconrel.2008.09.086
  • Danyuo Y, Obayemi JD, Dozie-Nwachukwu S et al (2014) Prodigiosin release from an implantable biomedical device: kinetics of localized cancer drug release. Mater Sci Eng C 42:734–745. https://doi.org/10.1016/j.msec.2014.06.008
  • Danyuo Y, Ani CJ, Obayemi JD et al (2015) Prodigiosin release from an implantable biomedical device: effect on cell viability. Adv Mater Res 1132:3–18. https://doi.org/10.4028/www.scientific.net/AMR.1132.3
  • Danyuo Y, Dozie-Nwachukwu S, Obayemi JD et al (2016) Swelling of poly(N-isopropylacrylamide) P(NIPA)-based hydrogels with bacterial-synthesized prodigiosin for localized cancer drug delivery. Mater Sci Eng C 59:19–29. https://doi.org/10.1016/j.msec.2015.09.090
  • Darshan N, Manonmani HK (2015) Prodigiosin and its potential applications. J Food Sci Technol 52:5393–5407. https://doi.org/10.1007/s13197-015-1740-4
  • De Clercq E, Holý A (2005) Acyclic nucleoside phosphonates: a key class of antiviral drugs. Nat Rev Drug Discov 4:928–940. https://doi.org/10.1038/nrd1877
  • de Miguel T, Rama JLR, Feijoo-Siota L et al (2016) Mechanisms of drug efflux and strategies to overcome them as a way to control microbial growth. In: Villa TG, Vinas M (eds) New weapons to control bacterial growth. Springer International Publishing AG Switzerland, Cham, pp 115–132. https://doi.org/10.1007/978-3-319-28368-5_6
  • Di Tommaso C, Bourges JL, Valamanesh F et al (2012) Novel micelle carriers for cyclosporin A topical ocular delivery: in vivo cornea penetration, ocular distribution and efficacy studies. Eur J Pharm Biopharm 81:257–264. https://doi.org/10.1016/j.ejpb.2012.02.014
  • Dodoo CC, Wang J, Basit AW et al (2017) Targeted delivery of probiotics to enhance gastrointestinal stability and intestinal colonisation. Int J Pharm 530:224–229. https://doi.org/10.1016/j.ijpharm.2017.07.068
  • Dorr RT (1992) Bleomycin pharmacology: mechanism of action and resistance, and clinical pharmacokinetics. Semin Oncol 19:3–8
  • Dozie-Nwachukwu SO, Danyuo Y, Obayemi JD et al (2017) Extraction and encapsulation of prodigiosin in chitosan microspheres for targeted drug delivery. Mater Sci Eng C 71:268–278. https://doi.org/10.1016/j.msec.2016.09.078
  • Egusquiaguirre SP, Igartua M, Hernández RM, Pedraz JL (2012) Nanoparticle delivery systems for cancer therapy: advances in clinical and preclinical research. Clin Transl Oncol 14:83–93. https://doi.org/10.1007/s12094-012-0766-6
  • Frušić-Zlotkin M, Soroka Y, Tivony R et al (2012) Penetration and biological effects of topically applied cyclosporin A nanoparticles in a human skin organ culture inflammatory model. Exp Dermatol 21:938–943. https://doi.org/10.1111/exd.12051
  • Fukata N, Uchida K, Kusuda T et al (2011) The effective therapy of cyclosporine A with drug delivery system in experimental colitis. J Drug Target 19:458–467. https://doi.org/10.3109/1061186X.2010.511224
  • Gabriel D, Mugnier T, Courthion H et al (2016) Improved topical delivery of tacrolimus: a novel composite hydrogel formulation for the treatment of psoriasis. J Control Release 242:16–24. https://doi.org/10.1016/j.jconrel.2016.09.007
  • Garrett IR, Gutierrez GE, Rossini G et al (2007) Locally delivered lovastatin nanoparticles enhance fracture healing in rats. J Orthop Res 25:1351–1357. https://doi.org/10.1002/jor.20391
  • Ghosh S, Das S, De AK et al (2017) Amphotericin B-loaded mannose modified poly(D,L- lactide-co-glycolide) polymeric nanoparticles for the treatment of visceral leishmaniasis: in vitro and in vivo approaches. RSC Adv 7:29575–29590. https://doi.org/10.1039/C7RA04951J
  • Gu H, Ho PL, Tong E et al (2003) Presenting vancomycin on nanoparticles to enhance antimicrobial activities. Nano Lett 3:1261–1263. https://doi.org/10.1021/nl034396z
  • Gu X, Zhang W, Liu J et al (2011) Preparation and characterization of a lovastatin-loaded protein-free nanostructured lipid carrier resembling high-density lipoprotein and evaluation of its targeting to foam cells. AAPS PharmSciTech 12:1200–1208. https://doi.org/10.1208/s12249-011-9668-0
  • Guada M, Beloqui A, Alhouayek M et al (2016a) Cyclosporine A-loaded lipid nanoparticles in inflammatory bowel disease. Int J Pharm 503:196–198. https://doi.org/10.1016/j.ijpharm.2016.03.012
  • Guada M, Beloqui A, Kumar MNVR et al (2016b) Reformulating cyclosporine A (CsA): more than just a life cycle management strategy. J Control Release 225:269–282. https://doi.org/10.1016/j.jconrel.2016.01.056
  • Guada M, Lana H, Gil AG et al (2016c) Cyclosporine A lipid nanoparticles for oral administration: pharmacodynamics and safety evaluation. Eur J Pharm Biopharm 101:112–118. https://doi.org/10.1016/j.ejpb.2016.01.011
  • Guo C, Zhang Y, Yang Z et al (2015) Nanomicelle formulation for topical delivery of cyclosporine A into the cornea: in vitro mechanism and in vivo permeation evaluation. Sci Rep 5:12968. https://doi.org/10.1038/srep12968
  • Hachicha W, Kodjikian L, Fessi H (2006) Preparation of vancomycin microparticles: importance of preparation parameters. Int J Pharm 324:176–184. https://doi.org/10.1016/j.ijpharm.2006.06.005
  • Han W, Yin G, Pu X et al (2017) Glioma targeted delivery strategy of doxorubicin-loaded liposomes by dual-ligand modification. J Biomater Sci Polym Ed 28:1695–1712. https://doi.org/10.1080/09205063.2017.1348739
  • Harisa GI, Alomrani AH, Badran MM (2017) Simvastatin-loaded nanostructured lipid carriers attenuate the atherogenic risk of erythrocytes in hyperlipidemic rats. Eur J Pharm Sci 96:62–71. https://doi.org/10.1016/j.ejps.2016.09.004
  • Hermans K, Van Den Plas D, Schreurs E et al (2014) Cytotoxicity and anti-inflammatory activity of cyclosporine a loaded PLGA nanoparticles for ocular use. Pharmazie 69:32–37. https://doi.org/10.1691/ph.2014.2206
  • Honary S, Ebrahimi P, Hadianamrei R (2014) Optimization of particle size and encapsulation efficiency of vancomycin nanoparticles by response surface methodology. Pharm Dev Technol 19:987–998. https://doi.org/10.3109/10837450.2013.846375
  • Hou Z, Wei H, Wang Q et al (2009) New method to prepare mitomycin c loaded pla-nanoparticles with high drug entrapment efficiency. Nanoscale Res Lett 4:732–737. https://doi.org/10.1007/s11671-009-9312-z
  • Hwang M-R, Kim JO, Lee JH et al (2010) Gentamicin-loaded wound dressing with polyvinyl alcohol/dextran hydrogel: gel characterization and in vivo healing evaluation. AAPS PharmSciTech 11:1092–1103. https://doi.org/10.1208/s12249-010-9474-0
  • Iihoshi H, Ishihara T, Kuroda S et al (2017) Aclarubicin, an anthracycline anti-cancer drug, fluorescently contrasts mitochondria and reduces the oxygen consumption rate in living human cells. Toxicol Lett 277:109–114. https://doi.org/10.1016/j.toxlet.2017.06.006
  • Insua I, Majok S, Peacock AFA et al (2017a) Preparation and antimicrobial evaluation of polyion complex (PIC) nanoparticles loaded with polymyxin B. Eur Polym J 87:478–486. https://doi.org/10.1016/j.eurpolymj.2016.08.023
  • Insua I, Zizmare L, Peacock AFA et al (2017b) Polymyxin B containing polyion complex (PIC) nanoparticles: improving the antimicrobial activity by tailoring the degree of polymerisation of the inert component. Sci Rep 7:9396. https://doi.org/10.1038/s41598-017-09667-3
  • Inweregbu K, Dave J, Pittard A (2005) Nosocomial infections. Contin Educ Anaesthesia, Crit Care Pain 5:14–17. https://doi.org/10.1093/bjaceaccp/mki006
  • Ismaiel AA, Ahmed AS, Hassan IA et al (2017) Production of paclitaxel with anticancer activity by two local fungal endophytes, Aspergillus fumigatus and Alternaria tenuissima. Appl Microbiol Biotechnol 101:5831–5846. https://doi.org/10.1007/s00253-017-8354-x
  • Italia JL, Bhatt DK, Bhardwaj V et al (2007) PLGA nanoparticles for oral delivery of cyclosporine: nephrotoxicity and pharmacokinetic studies in comparison to Sandimmune Neoral. J Control Release 119:197–206. https://doi.org/10.1016/j.jconrel.2007.02.004
  • Jain K, Verma AK, Mishra PR, Jain NK (2015) Characterization and evaluation of amphotericin B loaded MDP conjugated poly(propylene imine) dendrimers. Nanomedicine Nanotechnology, Biol Med 11:705–713. https://doi.org/10.1016/j.nano.2014.11.008
  • Jain A, Doppalapudi S, Domb AJ, Khan W (2016) Tacrolimus and curcumin co-loaded liposphere gel: synergistic combination towards management of psoriasis. J Control Release 243:132–145. https://doi.org/10.1016/j.jconrel.2016.10.004
  • Jia M, Li Y, Yang X et al (2014a) Development of both methotrexate and mitomycin C loaded PEGylated chitosan nanoparticles for targeted drug codelivery and synergistic anticancer effect. ACS Appl Mater Interfaces 6:11413–11423. https://doi.org/10.1021/am501932s
  • Jia Y, Ji J, Wang F et al (2014b) Formulation, characterization, and in vitro/vivo studies of aclacinomycin A-loaded solid lipid nanoparticles. Drug Deliv 7544:1–9. https://doi.org/10.3109/10717544.2014.974001
  • Jun Z, Daxin Z (2016) Improvement of oral bioavailability of lovastatin by using nanostructured lipid carriers. J Drug Des Dev Ther 2015(9):5269–5275
  • Kalhapure RS, Suleman N, Mocktar C et al (2015) Nanoengineered drug delivery systems for enhancing antibiotic therapy. J Pharm Sci 104:872–905. https://doi.org/10.1002/jps.24298
  • Khan I, Oh D (2016) Integration of nisin into nanoparticles for application in foods. Innovat Food Sci Emerg Technol 34:376–384. https://doi.org/10.1016/j.ifset.2015.12.013
  • Kojima R, Yoshida T, Tasaki H et al (2015) Release mechanisms of tacrolimus-loaded PLGA and PLA microspheres and immunosuppressive effects of the microspheres in a rat heart transplantation model. Int J Pharm 492:20–27. https://doi.org/10.1016/j.ijpharm.2015.07.004
  • Kullberg M, Mann K, Anchordoquy TJ (2012) Targeting Her-2+ breast cancer cells with bleomycin immunoliposomes linked to LLO. Mol Pharm 9:2000–2008. https://doi.org/10.1021/mp300049n
  • Kumeria T, Mon H, Aw MS et al (2015) Advanced biopolymer-coated drug-releasing titania nanotubes (TNTs) implants with simultaneously enhanced osteoblast adhesion and antibacterial properties. Colloids Surf B Biointerf 130:255–263. https://doi.org/10.1016/j.colsurfb.2015.04.021
  • Lee DA, Lee TC, Corres AE, Kirada S (1990) Effects of mifhramycin, mitomycin, daunorubicin, and bleomycin on human subconjuncfival fibroblasf attachment and proliferation. Investig Ophthalmol Vis Sci 31:2136–2144
  • Lemes AC, Sala L, Ores J, da C et al (2016) A review of the latest advances in encrypted bioactive peptides from protein-rich waste. Int J Mol Sci. https://doi.org/10.3390/ijms17060950
  • Leung SSY, Wong J, Guerra HV et al (2017) Porous mannitol carrier for pulmonary delivery of cyclosporine A nanoparticles. AAPS J 19:578–586. https://doi.org/10.1208/s12248-016-0039-3
  • Li Y, Zhang G, Pfeifer BA (2014) Current and emerging options for taxol production. In: Advances in biochemical engineering/biotechnology. Springer, Berlin, pp 405–425
  • Li Y, Liu L, Qu X et al (2015) Drug delivery property, antibacterial performance and cytocompatibility of gentamicin loaded poly(lactic-co-glycolic acid) coating on porous magnesium scaffold. Mater Technol 30:B96–B103. https://doi.org/10.1179/1753555714y.0000000194
  • Li X, Muller RH, Keck CM, Bou-Chacra NA (2016) Mucoadhesive dexamethasone acetate-polymyxin B sulfate cationic ocular nanoemulsion – novel combinatorial formulation concept. Pharmazie 71:327–333. https://doi.org/10.1691/ph.2016.5190
  • Lin J, Li Y, Wu H et al (2015) Tumor-targeted co-delivery of mitomycin C and 10-hydroxycamptothecin via micellar nanocarriers for enhanced anticancer efficacy. RSC Adv 5:23022–23033. https://doi.org/10.1039/C4RA14602F
  • Liu D, Yang F, Xiong F, Gu N (2016) The smart drug delivery system and its clinical potential. Theranostics 6:1306–1323. https://doi.org/10.7150/thno.14858
  • Liu X-J, Li L, Liu X-J et al (2017) Mithramycin-loaded mPEG-PLGA nanoparticles exert potent antitumor efficacy against pancreatic carcinoma. Int J Nanomed 12:5255–5269. https://doi.org/10.2147/IJN.S139507
  • Lombó F, Menéndez N, Salas JA, Méndez C (2006) The aureolic acid family of antitumor compounds: structure, mode of action, biosynthesis, and novel derivatives. Appl Microbiol Biotechnol 73:1–14. https://doi.org/10.1007/s00253-006-0511-6
  • Loveymi BD, Jelvehgari M, Zakeri-Milani P, Valizadeh H (2012) Design of vancomycin RS-100 nanoparticles in order to increase the intestinal permeability. Adv Pharm Bull 2:43–56. https://doi.org/10.5681/apb.2012.007
  • Lu W, Wan J, Zhang Q et al (2007) Aclarubicin-loaded cationic albumin-conjugated pegylated nanoparticle for glioma chemotherapy in rats. Int J Cancer 120:420–431. https://doi.org/10.1002/ijc.22296
  • Malakooti N, Alexander C, Alvarez-Lorenzo C (2015) Imprinted contact lenses for sustained release of polymyxin B and related antimicrobial peptides. J Pharm Sci 104:3386–3394. https://doi.org/10.1002/jps.24537
  • Malinovskaya Y, Melnikov P, Baklaushev V et al (2017) Delivery of doxorubicin-loaded PLGA nanoparticles into U87 human glioblastoma cells. Int J Pharm 524:77–90. https://doi.org/10.1016/j.ijpharm.2017.03.049
  • Martin C, Low WL, Gupta A et al (2015) Strategies for antimicrobial drug delivery to biofilm. Curr Pharm Des 21:43–66. https://doi.org/10.2174/1381612820666140905123529
  • Matsuru H, Shozo M, Hitoshi S et al (1979) Increased lymphatic delivery of bleomycin by microsphere in oil emulsion and its effect on lymph node metastasis. Int J Pharm 2:245–256. https://doi.org/10.1016/0378-5173(79)90031-0
  • Mazzoli R, Riedel K, Pessione E (2017) Bioactive compounds from microbes. Front Microbiol 8:392. https://doi.org/10.3389/fmicb.2017.00392
  • McNally MA, Ferguson JY, Lau ACK et al (2016) Single-stage treatment of chronic osteomyelitis with a new absorbable, gentamicin-loaded, calcium sulphate/hydroxyapatite biocomposite: a prospective series of 100 cases. Bone Joint J 98–B:1289–1296. https://doi.org/10.1302/0301-620X.98B9.38057
  • Moeller A, Ask K, Warburton D et al (2008) The bleomycin animal model: a useful tool to investigate treatment options for idiopathic pulmonary fibrosis? Int J Biochem Cell Biol 40:362–382. https://doi.org/10.1016/j.biocel.2007.08.011
  • Mohammed Fayaz A, Girilal M, Mahdy SA et al (2011) Vancomycin bound biogenic gold nanoparticles: a different perspective for development of anti VRSA agents. Process Biochem 46:636–641. https://doi.org/10.1016/j.procbio.2010.11.001
  • Moraes Moreira Carraro TC, Altmeyer C, Maissar Khalil N, Mara Mainardes R (2017) Assessment of in vitro antifungal efficacy and in vivo toxicity of Amphotericin B-loaded PLGA and PLGA-PEG blend nanoparticles. J Mycol Med. https://doi.org/10.1016/j.mycmed.2017.07.004
  • Morelli L, Capurso L (2012) FAO/WHO guidelines on probiotics. J Clin Gastroenterol 46:S1–S2. https://doi.org/10.1097/MCG.0b013e318269fdd5
  • Muñoz-Muñoz F, Ruiz JC, Alvarez-Lorenzo C et al (2009) Novel interpenetrating smart polymer networks grafted onto polypropylene by gamma radiation for loading and delivery of vancomycin. Eur Polym J 45:1859–1867. https://doi.org/10.1016/j.eurpolymj.2009.04.023
  • Nassar T, Rom A, Nyska A, Benita S (2009) Novel double coated nanocapsules for intestinal delivery and enhanced oral bioavailability of tacrolimus, a P-gp substrate drug. J Control Release 133:77–84. https://doi.org/10.1016/j.jconrel.2008.08.021
  • Nastruzzi C, Capretto M et al (2012) Mithramycin encapsulated in polymeric micelles by microfluidic technology as novel therapeutic protocol for beta-thalassemia. Int J Nanomed 307. https://doi.org/10.2147/IJN.S25657
  • Nehate C, Jain S, Saneja A et al (2014) Paclitaxel formulations: challenges and novel delivery options. Curr Drug Deliv 11:666–686. https://doi.org/10.2174/1567201811666140609154949
  • Nguyen GKT, Zhang S, Nguyen NTK et al (2011) Discovery and characterization of novel cyclotides originated from chimeric precursors consisting of albumin-1 chain a and cyclotide domains in the fabaceae family. J Biol Chem 286:24275–24287. https://doi.org/10.1074/jbc.M111.229922
  • Obayemi JD, Danyuo Y, Dozie-Nwachukwu S et al (2016) PLGA-based microparticles loaded with bacterial-synthesized prodigiosin for anticancer drug release: effects of particle size on drug release kinetics and cell viability. Mater Sci Eng C 66:51–65. https://doi.org/10.1016/j.msec.2016.04.071
  • Öncel P, Çetin K, Topçu AA et al (2017) Molecularly imprinted cryogel membranes for mitomycin C delivery. J Biomater Sci Polym Ed 28:519–531. https://doi.org/10.1080/09205063.2017.1282772
  • Pearce AK, Simpson JD, Fletcher NL et al (2017) Localised delivery of doxorubicin to prostate cancer cells through a PSMA-targeted hyperbranched polymer theranostic. Biomaterials 141:330–339. https://doi.org/10.1016/j.biomaterials.2017.07.004
  • Pettersen EF, Goddard TD, Huang CC et al (2004) UCSF Chimera--a visualization system for exploratory research and analysis. J Comput Chem 25(13):1605–1612. https://doi.org/10.1002/jcc.20084
  • Pishbin F, Mouriño V, Flor S et al (2014) Electrophoretic deposition of gentamicin-loaded bioactive glass/chitosan composite coatings for orthopaedic implants. ACS Appl Mater Interfaces 6:8796–8806. https://doi.org/10.1021/am5014166
  • Popat KC, Eltgroth M, LaTempa TJ et al (2007) Decreased Staphylococcus epidermis adhesion and increased osteoblast functionality on antibiotic-loaded titania nanotubes. Biomaterials 28:4880–4888. https://doi.org/10.1016/j.biomaterials.2007.07.037
  • Posadowska U, Brzychczy-Włoch M, Pamuła E (2015) Gentamicin loaded PLGA nanoparticles as local drug delivery system for the osteomyelitis treatment. Acta Bioeng Biomech 17:41–47. https://doi.org/10.5277/ABB-00188-2014-02
  • Pradeepa U, Bhat K, Vidya SM (2017) Nisin gold nanoparticles assemble as potent antimicrobial agent against Enterococcus faecalis and Staphylococcus aureus clinical isolates. J Drug Deliv Sci Technol 37:20–27. https://doi.org/10.1016/j.jddst.2016.11.002
  • Prombutara P, Kulwatthanasal Y, Supaka N, Sramala I (2012) Production of nisin-loaded solid lipid nanoparticles for sustained antimicrobial activity. Food Control 24:184–190. https://doi.org/10.1016/j.foodcont.2011.09.025
  • Ranganath SH, Fu Y, Arifin DY et al (2010) The use of submicron/nanoscale PLGA implants to deliver paclitaxel with enhanced pharmacokinetics and therapeutic efficacy in intracranial glioblastoma in mice. Biomaterials 31:5199–5207. https://doi.org/10.1016/j.biomaterials.2010.03.002
  • Rastegari B, Karbalaei-Heidari HR, Zeinali S, Sheardown H (2017) The enzyme-sensitive release of prodigiosin grafted β-cyclodextrin and chitosan magnetic nanoparticles as an anticancer drug delivery system: synthesis, characterization and cytotoxicity studies. Colloids Surfaces B Biointerfaces 158:589–601. https://doi.org/10.1016/j.colsurfb.2017.07.044
  • Ruiz JC, Alvarez-Lorenzo C, Taboada P et al (2008) Polypropylene grafted with smart polymers (PNIPAAm/PAAc) for loading and controlled release of vancomycin. Eur J Pharm Biopharm 70:467–477. https://doi.org/10.1016/j.ejpb.2008.05.020
  • Sandri G, Bonferoni MC, Gökçe EH et al (2010) Chitosan-associated SLN: in vitro and ex vivo characterization of cyclosporine A loaded ophthalmic systems. J Microencapsul 27:735–746. https://doi.org/10.3109/02652048.2010.517854
  • Scott D, Rohr J, Bae Y (2011) Nanoparticulate formulations of mithramycin analogs for enhanced cytotoxicity. Int J Nanomed 6:2757–2767. https://doi.org/10.2147/IJN.S25427
  • Serrano DR, Lalatsa A (2017) Oral amphotericin B: the journey from bench to market. J Drug Deliv Sci Technol:1–9. https://doi.org/10.1016/j.jddst.2017.04.017
  • Severino P, Chaud MV, Shimojo A et al (2015) Sodium alginate-cross-linked polymyxin B sulphate-loaded solid lipid nanoparticles: antibiotic resistance tests and HaCat and NIH/3T3 cell viability studies. Colloids Surfaces B Biointerfaces 129:191–197. https://doi.org/10.1016/j.colsurfb.2015.03.049
  • Sharma S, Bano S, Ghosh AS et al (2016) Silk fibroin nanoparticles support in vitro sustained antibiotic release and osteogenesis on titanium surface. Nanomed Nanotechnol, Biol Med 12:1193–1204. https://doi.org/10.1016/j.nano.2015.12.385
  • Sharma A, Arora M, Goyal AK, Rath G (2017) Spray dried formulation of 5-fluorouracil embedded with probiotic biomass: in vitro and in vivo studies. Probiotics Antimicrob Proteins 9:310–322. https://doi.org/10.1007/s12602-017-9258-x
  • Shatskaya NV, Levina AS, Repkova MN et al (2013) Delivery of bleomycin A5 into cells using TiO2 nanoparticles to enhance the degradation of intracellular DNA. Nanotechnol Russ 8:277–282. https://doi.org/10.1134/S1995078013020134
  • Shin SB, Cho HY, Kim DD et al (2010) Preparation and evaluation of tacrolimus-loaded nanoparticles for lymphatic delivery. Eur J Pharm Biopharm 74:164–171. https://doi.org/10.1016/j.ejpb.2009.08.006
  • Singh R, Smitha MS, Singh SP (2014) The role of nanotechnology in combating multi-drug resistant bacteria. J Nanosci Nanotechnol 14:4745–4756. https://doi.org/10.1166/jnn.2014.9527
  • Singh R, Kumar M, Mittal A, Mehta PK (2017a) Microbial metabolites in nutrition, healthcare and agriculture. 3 Biotech 7:1–14. https://doi.org/10.1007/s13205-016-0586-4
  • Singh B, Jang Y, Maharjan S et al (2017b) Combination therapy with doxorubicin-loaded galactosylated poly(ethyleneglycol)-lithocholic acid to suppress the tumor growth in an orthotopic mouse model of liver cancer. Biomaterials 116:130–144. https://doi.org/10.1016/j.biomaterials.2016.11.040
  • Souza ACO, Nascimento AL, de Vasconcelos NM et al (2015) Activity and in vivo tracking of Amphotericin B loaded PLGA nanoparticles. Eur J Med Chem 95:267–276. https://doi.org/10.1016/j.ejmech.2015.03.022
  • Steffes VM, Murali MM, Park Y et al (2017) Distinct solubility and cytotoxicity regimes of paclitaxel-loaded cationic liposomes at low and high drug content revealed by kinetic phase behavior and cancer cell viability studies. Biomaterials 145:242–255. https://doi.org/10.1016/j.biomaterials.2017.08.026
  • Stichtenoth G, Haegerstrand-Björkman M, Walter G et al (2017) Comparison of polymyxin E and polymyxin B as an additive to pulmonary surfactant in Escherichia coli pneumonia of ventilated neonatal rabbits. Biomed Hub 2:4–4. https://doi.org/10.1159/000475877
  • Sun X, Sun P, Li B et al (2016) A new drug delivery system for Mitomycin C to improve intravesical instillation. Mater Des 110:849–857. https://doi.org/10.1016/j.matdes.2016.08.058
  • Swieringa AJ, Goosen JHM, Jansman FGA, Tulp NJA (2008) In vivo pharmacokinetics of a gentamicin-loaded collagen sponge in acute periprosthetic infection: serum values in 19 patients. Acta Orthop 79:637–642. https://doi.org/10.1080/17453670810016650
  • Thell K, Hellinger R, Schabbauer G, Gruber CW (2014) Immunosuppressive peptides and their therapeutic applications. Drug Discov Today 19:645–653. https://doi.org/10.1016/j.drudis.2013.12.002
  • Tomasz M (1995) Mitomycin C: small, fast and deadly (but very selective). Chem Biol 2:575–579. https://doi.org/10.1016/1074-5521(95)90120-5
  • Umeyor EC, Kenechukwu FC, Ogbonna JD et al (2012) Preparation of novel solid lipid microparticles loaded with gentamicin and its evaluation in vitro and in vivo. J Microencapsul 29:296–307. https://doi.org/10.3109/02652048.2011.651495
  • Umezawa H, Maeda K, Takeuchi T, Okami Y (1966) New antibiotics, bleomycin A and B. J Antibiot (Tokyo) 19:200–209
  • van de Donk NWCJ, Kamphuis MMJ, Lokhorst HM, Bloema C (2002) The cholesterol lowering drug lovastatin induces cell death in myeloma plasma cells. Leukemia 16:1362–1371. https://doi.org/10.1038/sj.leu.2402501
  • Van De Ven H, Paulussen C, Feijens PB et al (2012) PLGA nanoparticles and nanosuspensions with amphotericin B: potent in vitro and in vivo alternatives to Fungizone and AmBisome. J Control Release 161:795–803. https://doi.org/10.1016/j.jconrel.2012.05.037
  • Varankovich N, Martinez MF, Nickerson MT, Korber DR (2017) Survival of probiotics in pea protein-alginate microcapsules with or without chitosan coating during storage and in a simulated gastrointestinal environment. Food Sci Biotechnol 26:189–194. https://doi.org/10.1007/s10068-017-0025-2
  • Wang K, Qi J, Weng T et al (2014) Enhancement of oral bioavailability of cyclosporine A: comparison of various nanoscale drug-delivery systems. Int J Nanomed 9:4991–4999. https://doi.org/10.2147/IJN.S72560
  • Wang Y, Ke X, Voo ZX et al (2016) Biodegradable functional polycarbonate micelles for controlled release of amphotericin B. Acta Biomater 46:211–220. https://doi.org/10.1016/j.actbio.2016.09.036
  • Wang D, Ren Y, Shao Y et al (2017) Facile preparation of doxorubicin-loaded and folic acid-conjugated carbon nanotubes@poly(N-vinyl pyrrole) for targeted synergistic chemo-photothermal cancer treatment. Bioconjug Chem. https://doi.org/10.1021/acs.bioconjchem.7b00515
  • Wei Z, Hao J, Yuan S et al (2009) Paclitaxel-loaded Pluronic P123/F127 mixed polymeric micelles: formulation, optimization and in vitro characterization. Int J Pharm 376:176–185. https://doi.org/10.1016/j.ijpharm.2009.04.030
  • WHO (2014) Antimicrobial resistance: gloval report of surveillance
  • Wong PT, Choi SK (2015) Mechanisms of drug release in nanotherapeutic delivery systems. Chem Rev 115:3388–3432. https://doi.org/10.1021/cr5004634
  • Wu Y, Wang Z, Liu G et al (2015) Novel simvastatin-loaded nanoparticles based on cholic acid-core star-shaped PLGA for breast cancer treatment. J Biomed Nanotechnol 11:1247–1260. https://doi.org/10.1166/jbn.2015.2068
  • Xiao H, Li W, Qi R et al (2012) Co-delivery of daunomycin and oxaliplatin by biodegradable polymers for safer and more efficacious combination therapy. J Control Release 163:304–314. https://doi.org/10.1016/j.jconrel.2012.06.004
  • Xu W, Ling P, Zhang T (2014) Toward immunosuppressive effects on liver transplantation in rat model: tacrolimus loaded poly(ethylene glycol)-poly(d,l-lactide) nanoparticle with longer survival time. Int J Pharm 460:173–180. https://doi.org/10.1016/j.ijpharm.2013.10.035
  • Xu J, Xu B, Shou D et al (2015) Preparation and evaluation of vancomycin-loaded N-trimethyl chitosan nanoparticles. Polymers (Basel) 7:1850–1870. https://doi.org/10.3390/polym7091488
  • Yang Z, Tan Y, Chen M et al (2012) Development of amphotericin B-loaded cubosomes through the solEmuls technology for enhancing the oral bioavailability. AAPS PharmSciTech 13:1483–1491. https://doi.org/10.1208/s12249-012-9876-2
  • Yang C, Uertz J, Chithrani D (2016) Colloidal gold-mediated delivery of bleomycin for improved outcome in chemotherapy. Nanomaterials 6:48. https://doi.org/10.3390/nano6030048
  • Yoshida T, Nakanishi K, Yoshioka T et al (2016) Oral tacrolimus oil formulations for enhanced lymphatic delivery and efficient inhibition of T-cell’s interleukin-2 production. Eur J Pharm Biopharm 100:58–65. https://doi.org/10.1016/j.ejpb.2015.12.006
  • Yu Z, Yan B, Gao L et al (2015) Targeted delivery of bleomycin: a comprehensive anticancer review. Curr Cancer Drug Targets 16:509–521. https://doi.org/10.2174/1568009616666151130213910
  • Zakeri-Milani P, Loveymi BD, Jelvehgari M, Valizadeh H (2013) The characteristics and improved intestinal permeability of vancomycin PLGA-nanoparticles as colloidal drug delivery system. Colloids Surfaces B Biointerfaces 103:174–181. https://doi.org/10.1016/j.colsurfb.2012.10.021
  • Zamorano-Leon JJ, Hernandez-Fisac I, Guerrero S et al (2016) New strategy of tacrolimus administration in animal model based on tacrolimus-loaded microspheres. Transpl Immunol 36:9–13. https://doi.org/10.1016/j.trim.2016.04.004
  • Zhang Z, Bu H, Gao Z et al (2010) The characteristics and mechanism of simvastatin loaded lipid nanoparticles to increase oral bioavailability in rats. Int J Pharm 394:147–153. https://doi.org/10.1016/j.ijpharm.2010.04.039
  • Zhang H, Gao Y, Lv W et al (2011) Preparation of bleomycin A2–PLGA microspheres and related in vitro and in vivo studies. J Pharm Sci 100:2790–2800. https://doi.org/10.1002/jps.22514
  • Zhang H, Wang C, Chen B, Wang X (2012) Daunorubicin-TiO 2 nanocomposites as a “smart” pH-responsive drug delivery system. Int J Nanomed 7:235–242. https://doi.org/10.2147/IJN.S27722
  • Zhang L, Zhao ZL, Wei XH, Liu JH (2013) Preparation and in vitro and in vivo characterization of cyclosporin A-loaded, PEGylated chitosan-modified, lipid-based nanoparticles. Int J Nanomed 8:601–610. https://doi.org/10.2147/IJN.S39685
  • Zhang P, Yang X, He Y et al (2017a) Preparation, characterization and toxicity evaluation of amphotericin B loaded MPEG-PCL micelles and its application for buccal tablets. Appl Microbiol Biotechnol 101:7357–7370. https://doi.org/10.1007/s00253-017-8463-6
  • Zhang Y, Liang RJ, Xu JJ et al (2017b) Efficient induction of antimicrobial activity with vancomycin nanoparticle-loaded poly(Trimethylene carbonate) localized drug delivery system. Int J Nanomed 12:1201–1214. https://doi.org/10.2147/IJN.S127715
  • Zhou X, Zhu H, Liu L et al (2010) A review: recent advances and future prospects of taxol-producing endophytic fungi. Appl Microbiol Biotechnol 86:1707–1717. https://doi.org/10.1007/s00253-010-2546-y
  • Zhou L, Zhang P, Chen Z et al (2017) Preparation, characterization, and evaluation of amphotericin B-loaded MPEG-PCL-g-PEI micelles for local treatment of oral Candida albicans. Int J Nanomed 12:4269–4283. https://doi.org/10.2147/IJN.S124264
  • Zhuk I, Jariwala F, Attygalle AB et al (2014) Self-defensive layer-by-layer films with bacteria-triggered antibiotic release. ACS Nano 8:7733–7745. https://doi.org/10.1021/nn500674g