Estudio de la función lagrimal y la superficie conjuntival en pacientes diabéticos

  1. L.C. Figueroa-Ortiz
  2. E. Jiménez Rodríguez
  3. A. García-Ben
  4. J. García-Campos
Journal:
Archivos de la Sociedad Española de Oftalmologia

ISSN: 0365-6691

Year of publication: 2011

Volume: 86

Issue: 4

Pages: 107-112

Type: Article

DOI: 10.1016/J.OFTAL.2010.12.010 DIALNET GOOGLE SCHOLAR lock_openOpen access editor

More publications in: Archivos de la Sociedad Española de Oftalmologia

Abstract

Objectives: This study was performed to investigate whether different grades of diabetic retinopathy correlate with tear and ocular surface function in diabetic patients without subjective symptoms of dry eye. Methods: A total of 129 eyes of 72 patients without dry eye, assessed using McMonnies questionnaire were recruited to the study. The tear film and ocular surface were evaluated using the Schirmer test, tear film break-up time (BUT), fluorescein and lissamine green staining test, and conjunctival impression cytology. The results were analysed. Results: A normal Schirmer test and BUT was obtained in 51 and 67% of the eyes of diabetics patients, respectively. Fluorescein and lissamine green staining were negative in 81 and 95% of the eyes. The area and density of goblet cells was 580.46±370µm² and 235.58±109.03 goblets cell/mm², respectively. Conclusions: Diabetic retinopathy patients without subjective symptoms of dry eye and normal Schirmer and BUT test showed pathological grades of squamous metaplasia.

Bibliographic References

  • Schultz, RO, Van Horn, DL, Peters, MA. (1981). Diabetic keratopathy. Tr Am Ophth Soc.. 79. 180
  • Dogru, M, Katakami, C, Inoue, M. (2001). Tear function and ocular surface changes in noninsulin-dependent diabetes mellitus. Ophthalmology.. 108. 586
  • Sánchez Thorin, J. (1998). The cornea in diabetes mellitus. Int Ophthalmol Clin.. 38. 19-36
  • Inoue, K, Kato, S, Ohara, C, Numaga, J, Amano, S, Oshita, T. (2001). Ocular and systemic factors relevant to diabetic keratoepitheliopathy. Cornea.. 20. 798-801
  • Saito, J, Enoki, M, Hara, M, Morishige, N, Chikama, T, Nishida, T. (2003). Correlation of corneal sensation, but not of basal or reflex tear secretion, with the stage of diabetic retinopathy. Cornea.. 22. 15
  • Goebbels, M. (2000). Tear secretion and tear film function in insulin dependent diabetics. Br J Ophthalmol.. 84. 19-21
  • Aragona, P, Giuffrida, S, Di Stefano, G, Ferreri, F, Di Benedetto, A, Bucolo, C. (2002). Ocular surface changes in type 1 diabetic patients. Adv Exp Med Biol.. 506. 667
  • Ozdemir, M, Buyukbese, MA, Cetinkaya, A, Ozdemir, G. (2003). Risk factors for ocular surface disorders in patients with diabetes mellitus. Diab Res Cl Pract.. 59. 195
  • (1991). Grading diabetic retinopathy from stereoscopic color fundus photograph- an extension of the modified Airlie House classification: ETDRS Report number 10. Ophthalmology.. 98. 786-806
  • Nichols, K, Nichols, J, Mitchell, L. (2004). The reliability and validity of McMonnies dry eye index. Cornea.. 23. 365
  • Smith, JA, Vitale, S, Reed, GF, Grieshaber, SA, Goodman, LA, Vanderhoof, VH. (2004). Dry eye signs and symptoms in women with premature ovarian failure. Arch Ophthalmol.. 122. 151
  • Lemp, MA, Hamill, JR. (1973). Factors affecting tear film breakup in normal eyes. Arch Ophthalmol.. 89. 103
  • Bron, AJ. (1997). The Doyne Lecture: reflections on the tears. Eye.. 11. 583-602
  • Franck, C. (1991). Fatty layer of the precorneal film in the «office eye syndrome». Acta Ophthalmol.. 69. 737
  • Nelson, JD, Havener, VR, Cameron, JD. (1983). Cellulose acetate impressions of the ocular surface: Dry eye states. Arch Ophthalmol.. 101. 1869
  • Tseng, SC. (1985). Staging of conjunctival squamous metaplasia by impression cytology. Ophthalmology.. 92. 728
  • Yu, L, Chen, X, Qin, G, Xie, H, Lv, P. (2008). Tear film function in type 2 diabetic patients with retinopathy. Ophthalmologica.. 222. 284
  • Cousen, P, Cackett, P, Bennett, H, Swa, K, Dhillon, B. (2007). Tear production and corneal sensitivity in diabetes. J Diabetes Complicat.. 21. 371
  • Yoon, K, Im, S, Seo, M. (2004). Changes of tear film and ocular surface in diabetes mellitus. Korean J Ophthalmol.. 18. 168
  • Lamberts, DW, Foster, CS, Perry, HD. (1979). Schirmer test after topical anesthesia and the tear meniscus height in normal eyes. Arch Ophthalmol.. 97. 1082
  • Mackie, I, Seal, D. (1981). The questionably dry eye. Br J Ophthalmol.. 65. 2-9
  • Manaviat, MR, Rashidi, M, Afkhami-Ardekani, M, Shoja, MR. (2008). Prevalence of dry eye syndrome and diabetic retinopathy in type 2 diabetic patients. BMC Ophthalmology. 8. 10
  • Tseng, SC, Hirst, LW, Maumenee, A. (1984). Possible mechanisms for the loss of goblet cells in mucin-deficient disorders. Ophthalmology.. 91. 545
  • Kim, J. (2000). The use of vital dyes in corneal disease. Curr Opin Ophthalmol.. 11. 241
  • Korb, D, Herman, J, Finnemore, V, Exford, J, Blackie, C. (2008). An evaluation of the efficacy of fluorescein, rose bengal, lissamine green and a new dye mixture for ocular surface staining. Eye Contact Lens.. 34. 61
  • Machado, L, Castro, R, Fontes, B. (2009). Staining patterns in dry eye syndrome: rose bengal versus lissamine green. Cornea. 28. 732
  • Nepp, J, Abela, C, Polzer, I, Derbolav, A, Wedrich, A. (2000). Is there a correlation between the severity of diabetic retinopathy and keratoconjunctivitis sicca?. Cornea. 19. 487
  • Tseng, SC, Hirst, LW, Farazdaghi, M, Green, WR. (1984). Goblet cell density and vascularization during conjunctival transdifferentiation. Invest Ophthalmol Vis Sci.. 25. 1168
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