Nuevos criterios de clasificación de lupus eritematoso sistémico
ISSN: 2171-9020
Year of publication: 2019
Issue Title: Supervivencia a largo plazo de pacientes tratados con nivolumab
Volume: 2
Issue: 46
Type: Article
More publications in: MPG Journal
Abstract
New classification criteria for systemic lupus erythematosus (SLE) jointly supported by the European League Against Rheumatism (EULAR) and the American College of Rheumatology (ACR) have been developed.This initiative had four phases: evaluation of antinuclear antibody (ANA) as an entry criterion; criteria reduction by Delphi and nominal group technique exercises; criteria definition and weighting based on criterion performance and on results of a multicriteria decision analysis and refinement of weights and threshold scores and validation compared with previous criteria in a new validation cohort of subjects. The 2019 EULAR/ACR classification criteria for SLE include positive ANA at least once as obligatory entry criterion; followed by criteria grouped in 7 clinical (constitutional, hematologic, neuropsychiatric, mucocutaneous, serosal, musculoskeletal, renal) and 3 immunologic (antiphospholipid antibodies, complement proteins, SLE-specific antibodies) domains. Patients accumulating ≥10 points are classified. In the validation cohort, the new criteria had a sensitivity of 96.1% and specificity of 93.4%.
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