Microwave Promoted Synthesis of a Rehabilitated Drug: Thalidomide

  1. Seijas, Julio 1
  2. Vázquez-Tato, M. 1
  3. González-Bande, Cristóbal 1
  4. Martínez, M. 1
  5. Pacios-López, Beatriz 1
  1. 1 Universidade de Santiago de Compostela
    info

    Universidade de Santiago de Compostela

    Santiago de Compostela, España

    ROR https://ror.org/030eybx10

Journal:
Synthesis

ISSN: 0039-7881,  1437-210X

Year of publication: 2004

Volume: 2001

Issue: 07

Type: Article

DOI: 10.1055/S-2001-14573 GOOGLE SCHOLAR lock_openOpen access editor

More publications in: Synthesis

Abstract

A new direct synthesis of thalidomide in high yield by microwave irradiation of N-phthaloyl-l-glutamic in the presence of thiourea is described. Thalidomide was also obtained in good yield from l-glutamic acid, phtalic anhydride and thiourea in a one-pot procedure.