Heterogenicidad del síndrome de Gorham-Stout: asociación a malformaciones linfáticas y venosas
- I. Somoza Argibay
- M. Díaz González
- L. Martínez Martínez
- Z. Ros Mar
- J.C. López-Gutiérrez
ISSN: 1695-4033, 1696-4608
Year of publication: 2003
Volume: 58
Issue: 6
Pages: 599-603
Type: Article
More publications in: Anales de Pediatría: Publicación Oficial de la Asociación Española de Pediatría ( AEP )
Abstract
Introduction Gorham-Stout syndrome is a rare disorder of unknown etiology characterized by osteolysis and microscopic proliferation of abnormal vessels. We report two cases of this syndrome associated with lymphatic and venous malformations. Case reports The first case is a 5-year-old boy with disseminated lymphangiomatosis of poor prognosis, with significant pleural involvement and osteolytic lesions. The second case is a 5-year-old girl with a diagnosis of Klippel-Trenaunay syndrome with significant skeletal involvement of the lower extremities and secondary pathological fracture. Conclusions Gorham-Stout syndrome may occasionally be associated with various lymphatic and venous malformations. Osteolysis and bone resorption may be induced by lymphatic bone involvement.