Temporal progression of the distribution of Streptococcus pneumoniae serotypes causing invasive pneumococcal disease in Galicia (Spain) and its relationship with resistance to antibiotics (period 2011-2021)

  1. Losada-Castillo, Isabel 3
  2. Santiago-Pérez, Isolina 1
  3. Juiz-Gonzalez, Pedro Miguel 2
  4. Méndez-Lage, Susana 2
  5. Purriños-Hermida, María Jesús 4
  6. Malvar, Alberto 1
  7. Agulla-Budiño, José Andrés 2
  1. 1 Servizo de Epidemioloxía, Dirección Xeral de Saúde Pública, Consellería de Sanidade, La Coruña, Santiago de Compostela, Spain
  2. 2 Servizo de Microbioloxía, Complexo Hospitalario Universitario de Ferrol, La Coruña, Ferrol, Spain
  3. 3 Servizo de Calidade Asistencial, Dirección Xeral de Asistencia Sanitaria, Consellería de sanidade, La Coruña, Santiago de Compostela, Spain
  4. 4 Servizo de Admisión, Complexo Hospitalario Universitario de Santiago, La Coruña, Santiago de Compostela, Spain
Revista:
Enfermedades Infecciosas y Microbiologia Clinica

ISSN: 0213-005X

Año de publicación: 2024

Volumen: 42

Número: 4

Páginas: 179-186

Tipo: Artículo

DOI: 10.1016/J.EIMC.2022.12.007 SCOPUS: 2-s2.0-85146538990 GOOGLE SCHOLAR lock_openAcceso abierto editor

Otras publicaciones en: Enfermedades Infecciosas y Microbiologia Clinica

Resumen

Introduction: Streptococcus pneumoniae causes serious diseases in the susceptible population. The 13-valent pneumococci conjugate vaccine (PCV13) was included in the children's calendar in 2011. The objective of the study was to analyze the evolution of pneumococcal serotypes and their resistance after PCV13. Methods: This study included the pneumococci serotyped in Galicia in 2011-2021. Antibiotic susceptibility was analyzed following EUCAST criteria. The data was analyzed in 3 sub-periods: initial (2011-2013), middle (2014-2017) and final (2018-2021). The prevalence of serotypes and their percentage of resistance to the most representative antibiotics were calculated. Results: A total of 2.869 isolates were included. Initially, 42.7% isolates presented capsular types included in PCV13, compared to 15.4% at the end. Those included in PCV20 and not in PCV13 and PCV15 were 12.5% at baseline and 41.3% at the end; 26.4% of the isolates throughout the study had serotypes not included in any vaccine. The prevalence of serotype 8 multiplied almost by 8 and that of 12F tripled. The 19A serotype was initially the most resistant, while the resistance of serotypes 11A and 15A increased throughout the study. Conclusions: The introduction of PCV13 in the pediatric population determined a change in pneumococcal serotypes towards those included in PCV20 and those not included in any vaccine. Serotype 19A was initially the most resistant and the 15A, not included in any vaccine, deserves special follow-up. Serotype 8, which increased the most, did not show remarkable resistance.

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