Vigilancia de la resistencia a antibióticos en enfermedad invasiva por Pseudomonas aeruginosa en Galicia: 2013-2014
- Lucía Martínez Lamas
- Isabel Paz
- Irene Rodríguez Conde
- Francisco J. Vasallo
- María Ángeles Pallarés
- Fernando Garcia Garrote
- Isabel Losada Castillo
- Xurxo Hervada Vidal
ISSN: 0304-4866, 1989-3922
Ano de publicación: 2018
Volume: 79
Número: 4
Páxinas: 114-119
Tipo: Artigo
Outras publicacións en: Galicia Clínica
Resumo
Introduction. The aim of this study is to know the antibiotic sensitivity of the Pseudomonas aeruginosa, which produces invasive infections in Galicia in 2013/2014, in the framework of the Surveillance Study of Antimicrobial Resistance. Methods. A total of 357 isolates of P. aeruginosa were analyzed in blood or CSF samples from 9 hospitals in Galicia. The variables were: origin, demographic data, sample type and antibiotic sensitivity. CLSI breakpoints were used. For each antibiotic we analyzed frequencies, cases/100.000 inhabitants, concordance of resistance and differences between hospitals, sex and age. Results. The majority of patients were male gender and the not-sensitives were superior in the 45 to 64 age group with significant differences to ciprofloxacin, imipenem, tobramycin and colistin. The overall not-sensitivity isolates was: piperacillin/tazobactam 18%, ciprofloxacin 28.7%, ceftazidime 17.1%, cefepime 19.7%, imipenem 23.1%, meropenem 22.1%, tobramycin 13.0%, amikacin 7.3% and colistin 4.4%. The cases/100,000 inhabitants were higher in men as age increasing. Without analyzing colistin, the 57.1% of the isolates were sensitives to other antibiotics studied (piperacillin/tazobactam, quinolones, ceftazidime, aminoglycosides, carbapenems), 19.4% were not-susceptible to only one antibiotic, 12. 2% to two, 3.7% to three, 5.1% to four and 2.0% to all antibiotics tested. Conclusions. Of the antibiotics tested, the most susceptible to P. aeruginosa were amikacin and colistin. Our data are consistent with the observed ones nationwide except colistin. Sensitivity patterns of P. aeruginosa should be periodically evaluated in each area and each hospital in order to assess the different therapeutic regimens.